Research on Light Therapy and Brain Fog

Brain fog is a term that encompasses a variety of cognitive impairments, such as memory, attention, and fatigue. Research on photobiomodulation (PBM) provides promising evidence for reducing it’s symptom severity.

Woman with curly hair holding her head, eyes closed, appearing fatigued or distressed

Signs and Symptoms of Brain Fog

Symptoms of brain fog include (Cleveland Clinic, 2024):

Difficulty concentrating
Fatigue
Forgetfulness
Mental exhaustion
Confusion
Troubles with word-finding
Slow thought process and reaction time.
Losing your train of thought

Is There a Biomarker for Brain Fog?

Because brain fog is a constellation of symptoms that can be tied to a variety of causes, and can be both chronic or acute, biomarkers would depend on the cause of each case of brain fog. However, cases across each condition have similarities including (Denno et al., 2025):

Difficulties with Cognitive Function
Subtle changes in working memory, processing speed, and sustained attention often show up on cognitive testing in people reporting brain fog. These can function as practical “behavioral biomarkers,” even when brain imaging or bloodwork appear normal.
Impaired Mental Clarity
Impaired mental clarity often appears as slower information processing and difficulty organizing thoughts or making decisions. Clinically, this can be reflected in reduced cognitive efficiency, even if accuracy on tasks remains intact.
Fatigue, Mood, and Daily Functioning
Brain fog often occurs alongside significant fatigue, anxiety, and depression. These overlapping symptoms can strongly reduce occupational quality of life, making it harder to meet deadlines, stay organized, and feel confident or emotionally steady at work.

Translucent brain illustration surrounded by clouds with warm light points, representing neural activity or cognitive processing

What Causes Symptoms of Brain Fog?

Symptoms of brain fog include (Cleveland Clinic, 2024):

Lifestyle factors such as poor sleep, jet lag, shift work, drug or alcohol use, excessive screentime.
Side effects from medications or treatments such as chemotherapy, antihistamines, or sleep medications.
Illness and conditions such as COVID-19, migraines, pregnancy, diabetes, or mental health conditions. (American Brain Foundation, 2025)

PBM Improves Cognition and Mood
One study by Lundie and colleagues (2025) found that after 2 continuous wave tPBM sessions 6 days apart, participants showed improvements in symptoms associated with brain fog, such as improved working memory, reaction time, and decreased depression and anxiety scores.
See the study
PBM Enhances Memory and Executive Function
Another study by Bowen and Arany (2023) found that 12 sessions of 14 minutes of 1070 nm light therapy resulted in an improvement in cognitive tests evaluating working memory, executive function, mental flexibility and reaction time.
See the study
Sleep Quality Improved with PBM
With insomnia being a common cause for brain fog, one study found that 10 minutes of tPBM across 3 days showed an improvement in subjective sleep quality, reduced daytime sleepiness, and normalized frontal delta activity due to chronic insomnia (Mehdizadeh, Farnam & Nikzad, 2025).
See the study

Attention & Memory

Authors:: Dr. Michael Lundie, Daniel Krawczyk, et al.
Published:: September 16, 2025
Sample size:: 8 (n=4 active, n=4 sham)

This 2025 pilot, randomized, double-blind study by Dr. Michael Lundie and colleagues investigated whether transcranial photobiomodulation via the Neuradiant 1070 could enhance cognitive performance and neurophysiological markers compared to a sham condition in healthy adults. Participants who received active tPBM demonstrated significantly faster reaction times (greater and sustained pupil dilation), improved working memory under high cognitive load, and increased physiological markers of attentional engagement relative to sham. Additional findings included greater pupil dilation during task performance - suggestive of enhanced neuromodulatory activity - and reductions in self-reported stress and mood symptoms in a majority of tPBM participants. Collectively, these results indicate that tPBM may acutely improve processing speed, attention, and cognitive efficiency, supporting its potential as a non-invasive tool for cognitive augmentation.

Read the full publication

AMSUS Military Medicine journal cover for 2024 Military Health System Research Symposium proceedings

Methods

Design & Participants:

A randomized, double-blind study involving eight adults (18–45 years), randomly assigned to either the tPBM group (n = 4) or a sham group (n = 4). Each participant completed two sessions, spaced approximately six days apart.

Intervention

tPBM group: received near-infrared light (1070 nm) over the dorsolateral prefrontal cortex (DLPFC) for 15 minutes per session. Sham group: wore the same device but received only a brief initial light cue without sustained stimulation.

Assesments

Cognitive battery including reaction time tasks (e.g., psychomotor vigilance), working memory measures, pupillometry, and Depression Anxiety Stress Scale (DASS-21).

Results

Processing Speed:

The tPBM group showed significantly faster reaction times compared to sham (plasticity and RT measures significant at p = .013 and p = .038).

Working Memory:

Comparison of high-load and composite kVcues between IPEM and sham conditions, shown as box plots across four kinase metrics with error bars

In high-load orientation trials, tPBM participants had significantly higher working memory capacity (K-values) than the sham group, suggesting better performance under cognitive load.

Pupillometry & Attention:

Line graph showing reaction time versus pupil dilation for sham and active groups, with active group trending upward and sham group trending downward

Participants receiving tPBM exhibited increased pupil dilation and greater consistency during tasks - physiological markers of heightened attentional engagement and potential involvement of neuromodulatory pathways (e.g., locus coeruleus-norepinephrine).

Psychological Metrics:

A majority of tPBM participants showed reductions in depression, anxiety, and stress scores, whereas sham controls did not show consistent improvements

FAQs

What results can be expected and when?

Types of results and their timelines vary depending on the individuals. However, a combination of research and anecdotal evidence from providers suggests some expected results to be the following: improved language capabilities, improvements in emotional regulation, decreased repetitive behaviours, and improved social skills/engagement. While some clients may see results very quickly, others may take a few months.

What is mitochondrial dysfunction?

Mitochondrial dysfunction is a term that encapsulates dysfunction in various operations of the mitochondria. With mitochondria being the main energy producers of the cell, dysfunction can lead to reduced ATP (energy) production, increased oxidative stress, and difficulty maintaining healthy cell function. When mitochondria can’t keep up with the body’s energy demands or fail to remove damaged components, it can affect brain function, muscle strength, immune response, and overall vitality. Mitochondrial dysfunction is linked to many conditions, including fatigue, neurodegeneration, and metabolic disorders (Zong et al., 2024).

How many PBM sessions will I need?

Benefits can often be noticed within a few sessions, especially related to sleep and mental clarity. For cognitive improvements, consistent use over several weeks or months is typically recommended. As AD is often referred to as a neurodegenerative disease with genetic components, incorporating light therapy as a regular lifestyle habit can support overall brain health and give your brain the best chance to stay at its most performing level over time.

Is PBM safe?

Yes. PBM is FDA-cleared for various applications and has a strong safety profile. It’s non-invasive, painless, and has no known serious side effects when used as directed.

References

American Brain Foundation. (n.d.). What is brain fog? https://www.americanbrainfoundation.org/what-is-brain-fog/

Bowen, R., & Arany, P. R. (2023). Use of either transcranial or whole-body photobiomodulation treatments improves COVID-19 brain fog. Journal of Biophotonics, 16(8), e202200391. https://doi.org/10.1002/jbio.202200391

Cleveland Clinic. (n.d.). Brain fog. https://my.clevelandclinic.org/health/symptoms/brain-fog

Denno, P., Zhao, S., Husain, M., & Hampshire, A. (2025). Defining brain fog across medical conditions. Trends in Neurosciences, 48(5), 330–348. https://doi.org/10.1016/j.tins.2025.01.003

Lundie, M., Koch, M., Villanueva, A., Nguyen, T., Garner, C., Satsangi, M., Advani, P., & Krawczyk, D. (2025). Illuminating cognitive performance: Assessing the role of transcranial photobiomodulation in augmenting cognition. Military Medicine, 190(Suppl. 2), 456–463. https://doi.org/10.1093/milmed/usaf227

Mehdizadeh, M., Farnam, A., & Nikzad, B. (2025). Transcranial photobiomodulation improves sleep quality, reduces daytime sleepiness, and modulates delta power in chronic insomnia: A randomized controlled trial. Lasers in Medical Science, 40(1), Article 451. https://doi.org/10.1007/s10103-025-04699-y